Preclinical studies for evaluation of antitumor effects and normal tissue toxicity of antibody conjugates

Gjorgieva Ackova, Darinka and Smilkov, Katarina and Janevik-Ivanovska, Emilija (2016) Preclinical studies for evaluation of antitumor effects and normal tissue toxicity of antibody conjugates. Macedonian Pharmaceutical Bulletin, 62(s). pp. 257-259.

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Abstract

Antibody conjugates are therapeutics that function through mediating alterations in antigen or receptor func¬tion, modulat¬ing the immune system (for example, changing Fc function and T cell activation) or delivering of a specific drug conjugated to antibody that targets a specific antigen. Four main classes using antibodies are investigated to target cytotoxic agents to cancer cells.Futhermore, dealing with the challenges in the process of target selection and selection of conjugate elements including the design of antibody formulation and toxicity assessment, is also imperative in the process of design of this type of therapeutics.

Item Type: Article
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Darinka Gorgieva Ackova
Date Deposited: 07 Jul 2016 11:05
Last Modified: 07 Jul 2016 11:05
URI: http://eprints.ugd.edu.mk/id/eprint/15949

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