Chemical analysis of the rituximab radioimmunoconjugates in lyophilized formulations intended for oncological applications

Gjorgieva Ackova, Darinka and Smilkov, Katarina and Makreski, Petre and Stafilov, Trajče and Janevik-Ivanovska, Emilija (2016) Chemical analysis of the rituximab radioimmunoconjugates in lyophilized formulations intended for oncological applications. In: 18th European Symposium on Radiopharmacy and Radiopharmaceuticals, 07-10 Apr 2016, Salzburg, Austria.

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Abstract

For a protein based drug including antibody based radiopharmaceuticals, a structural characterization is mandatory before any possible start of a clinical trial. Vibrational spectroscopic techniques, as Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy are one of the biophysical methods for structural characterization of proteins because of their sensitivity to the composition and architecture of molecules. Here we used vibrational spectroscopy to characterize the physico-chemical stability and structural changes of three immunoconjugates of rituximab, intended for labeling with radioisotope of choice (177Lu, 90Y and/or 68Ga), relevant for the stability of therapeutic/diagnostic antibodies during preparation, storage and/or transport.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Darinka Gorgieva Ackova
Date Deposited: 12 Jul 2016 10:26
Last Modified: 12 Jul 2016 10:26
URI: http://eprints.ugd.edu.mk/id/eprint/15946

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