Supramolecular hydrogen bonding patterns of co-crystals containing the Active Pharmaceutical Ingredient Phloroglucinol and N-heterocycles

Cvetkovski, Aleksandar and Vertolasi, Valerio and Ferratti, Valeria (2016) Supramolecular hydrogen bonding patterns of co-crystals containing the Active Pharmaceutical Ingredient Phloroglucinol and N-heterocycles. Acta Crystallographica Edition B. pp. 326-334. ISSN 2052-5206

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Abstract

The active pharmaceutical ingredient phloroglucinol (PHL) has been taken as an illustrative molecule to explore the intermolecular interactions which can be established with other molecular entities to build PHL-pharmaceutical co-crystals. The crystal structures of five newly synthesized co-crystals are reported, where PHL is crystallized with N-heterocycles, namely 2-hydroxy-6-methyl-pyridine (1), 2,4-dimethyl-6-hydroxy-pyrimidine (2), 4-phenyl-pyridine (3), 2-hydroxy-pyridine (4), and 2,3,5,6- tetramethylpyrazine (5). The structural characteristics of these co-crystals, as far as the hydrogen bonding networks and the crystalline architectures are concerned, are strongly dependent on the chemical features of the coformer molecules, as well as on their size and shape. A detailed analysis of the intermolecular interactions established in all the PHL cocrystals of known structures has allowed the recognition of some regularities in the packing modes that can be useful in the design of new supramolecular adducts forming predictable structural motifs.

Item Type: Article
Subjects: Natural sciences > Chemical sciences
Divisions: Faculty of Medical Science
Depositing User: Aleksandar Cvetkovski
Date Deposited: 15 Apr 2016 12:29
Last Modified: 01 Jun 2016 09:01
URI: http://eprints.ugd.edu.mk/id/eprint/15731

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