Systemic fungal infections in hematological malignancies

Kuzmanovski, Petar and Markovski, Velo (2015) Systemic fungal infections in hematological malignancies. In: International Symposium at Faculty of Medical Sciences “Current achievements and future perspectives in medical and biomedical research”, 24 Nov 2015, Stip, Macedonia.

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Abstract

Introduction: In few centers around the world within a period of several decades were made autopsy studies of patients with any kind of cancer for the purpose to find systemic (invasive) fungal infection. Objective: The objective of this paper is to find the relation between systemic (invasive) fungal infections and cancer. What’s the correlation and connections between the two of them and why is this so important for the modern medicine. Materials and methods: The data that we are going to use is from a research made in M.D. Anderson Cancer Center, Huston, Texas and from the medical book Carol A. Kauffman, Peter G. Pappas - Essentials of Clinical Mycology 2nd edition 2011. Results and discussions: Results from the research made in M.D. Anderson Cancer Centre show that 57% (1990-1999) and 68% (2000-2008) of the patients with leukemia have had some kind of an invasive fungal infection. Results documented in “Essential of Clinical Mycology” show that 26% of the patients with leukemia worldwide have had invasive fungal infectionconfirmedby a autopsy Authors assume that around 75% of the leukemia patients are with undiagnosed IFI during life. This rate lead to threating cancer patient with antifungal therapy, which bring us to the discovery that patient easily go in remission while threated with antifungal medicaments such as itraconazole or voriconazole. Also an importand data from this research is the change of the most commonly fungal pathogens, candida and aspergillus. We can see from the chart that before year 1990 the most common fungal infection were candida infections. Now we see that aspergillus has taken that place. This is due to involving of azole prophylaxis while threating leukemia. Conclusion: The autopsy show that average rate of leukemia patients with invasive fungal infection is 26%. The use of azole prophylaxis in the treatment of leukemia lowered the rate of systemic candidiasis in patient by 5 to 10%. When we treat cancer, we always have to think about the complications made from systemic fungal infectons, which can be easily cured and can bring remission to the patiens and prolong their lifes. Keywords Invasive fungal infections, leukemia, candida, aspergillus.

Item Type: Conference or Workshop Item (Poster)
Uncontrolled Keywords: Invasive fungal infections, leukemia, candida, aspergillus
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Dance Vasileva
Date Deposited: 10 Feb 2016 12:22
Last Modified: 10 Feb 2016 12:22
URI: http://eprints.ugd.edu.mk/id/eprint/15323

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