Drugs like risks factors for oral-facial clefts in newborn baby

Velickova, Nevenka (2011) Drugs like risks factors for oral-facial clefts in newborn baby. EPMA Journal, 2 (1, s51). ISSN 1878-5085

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Intruduction: A cleft is a gap in a body structure that results from incomplete closing of a specific structure during development. Clefts that occur in the lip and palate (roof of the mouth) are called oral-facial clefts. These birth defects occur very early in fetal development. The causes of these birth defects are not well understood. Cleft lips and palates are caused by a combination of genetic and environmental factors. Studies suggest that a number of genes, as well as environmental factors can cause oral-facial clefts. The aim of this study was to evaluate the risks factors, incidence, causes and symptoms of oral facial clefts at the children hospitalized in the children’s ward in Stip. This researches offer a preventive possibility to reduce appearance of oral-facial clefts in newborn baby. Material and methods: After birth, cleft lip and palate were diagnosed by physical exam. The risks factors and special exposure of their mothers during pregnancy were assessed. Also, the incidence, causes and symptoms at the children with oral facial clefts were evaluated. Their parents did n’t have oral-facial clefts. Results: The results indicated that during past 10 year children with oral facial clefts were borned in series in the same or closer month in the year (in the summer and the autumn). Also, was find that every year increased the number of children with oral-facial clefts and they were not associated with other syndrome. Children with oral-facial clefts have special problems and complication like feeding difficulties, ear infections and hearing loss. Conclusion: The obtain results suggest that environmental factors, such as drugs (including several different anti-seizure drugs) and maternal smoking, are risk factors for appearance of oral-facial clefts. We concluded that seasonal causes (such as pesticide exposure); maternal diet and vitamin intake; retinoids, which are members of the vitamin A family; anticonvulsant drugs; alcohol; cigarette use; nitrate compounds; organic solvents; parental exposure to lead; as teratogens increase the possibility of clefting. An increased risk for isolated oral-facial clefts was found in cases born to mothers treated with amoxicillin, phenytoin, oxprenolol, and thiethylperazine during the second and third month of pregnancy, which is the critical period for during fetal development.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Nevenka Velickova
Date Deposited: 23 Nov 2012 10:06
Last Modified: 26 Nov 2012 09:35
URI: http://eprints.ugd.edu.mk/id/eprint/1492

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