Etiopathogenetic Cellular Mechanisms in Oral Lichen Planus

Popovska, Mirjana and Radojkova-Nikolovska, Vera and Minovska, Ana and Muratovska, Ilijana and Mijovska, Aneta (2015) Etiopathogenetic Cellular Mechanisms in Oral Lichen Planus. International Journal of Science and Research (IJSR), 4 (11). pp. 1985-1989. ISSN 2319-7064

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Abstract

Abstract: Objective: to follow the immune status in patients with oral lichen planus (OLP), by assessing the level of T and B lymphocytes in the blood. Material and method: 54 patients with OLP and 50 healthy people were examined. Experimental group was divided into three subgroups: reticular, erythema-exudative and bullоus form. Both groups, control and experimental, were assessed for values of T and B lymphocytes in the blood in the Institute for Transfusion. Findings were statistically processed using the Student-t test. Results: In the phase of exacerbation in all three clinical forms of OLP, T and B cells in peripheral blood were increased, versus the control group (p<0.001). In the phase of remission in reticular, erythema-exudative and bullous form, slight decrease in the values of T and B cells was observed, but it was still above control values and with high significance (p<0.001), except for B lymphocytes in the reticular form where p <0.01. Conclusion: The increased values of T and B lymphocytes in the phase of exacerbation and remission, are explained with the chronicity of the process, which leads us to the conclusion that the immune system is reconstructed in terms of increased cell activity.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Ana Minovska
Date Deposited: 24 Dec 2015 09:30
Last Modified: 24 Dec 2015 09:30
URI: http://eprints.ugd.edu.mk/id/eprint/14700

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