Velickova, Nevenka and Milev, Mishko and Petrova, Biljana and Ruskovska, Tatjana and Sumanov, Gorgi and Nedeljkovik, Bojana and Gorgieva, Pale (2015) An increased micronucleus frequency predict the risc of cancer in healthy workers exposed on ionization. In: Šesti hrvatski kongres humane genetike, 5-7 Nov 2015, Split, Hrvatska.
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Abstract
Introduction: Chromosomal damage measurement is one of important ways to evaluate the toxicity, carcinogenicity, and mutagenicity of drugs, chemicals, and rays. The observation that chromosome damage can be caused by exposure to ionizing radiation or carcinogenic chemicals was among the first reliable evidence that physical and chemical agents can cause major alterations to the genetic material of eukaryotic cells. The Cytokinesis-Blocked Micronucleus (CBMN) assay also allowed us to score the abnormal nuclear shapes (ANS). The CBMN assay in human lymphocytes is one of the most commonly used methods for measuring DNA damage. Material and methods: The study population included 20 healthy workers exposed to ionizing radiation (radiologist, technicians and nurses) and 20 individuals healthy people not exposed on radiation. Results: We found an high frequency of micronuclei in healthy workers exposed on ionization in comparison with the control group (healthy people not exposed on ionization ). Also we evaluate other nuclear changes like nucleoplasmic bridges and binucleated cell with nuclear buds are biomarkers of chromosomal instability and major alterations in genetic material of the cells.
Conclusion: These results suggest that chromosomal instability is in the correlation with micronucleus frequencies and genetic load in healthy workers. The formation of micronucleus and other changes indicates that healthy workers are exposed on clastogenic and aneugenic agents like ionizing radiation and have chromosomal instability and risk of cancer.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Nevenka Velickova |
| Date Deposited: | 23 Dec 2015 13:09 |
| Last Modified: | 27 Jan 2016 11:16 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/14675 |
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