Significant Improvements in Glycaemic Control with BIAsp 30 in Clinical Reality: Experience from Clinical Practice in Macedonia

Milenkovic, Tatjana and Smokovski, Ivica and Kulumova, Elena and Stojanovski, Nikola and Aleksov, Branko (2009) Significant Improvements in Glycaemic Control with BIAsp 30 in Clinical Reality: Experience from Clinical Practice in Macedonia. In: ADA Congress 2009, 05-09 June 2009, New Orleans, USA.

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Abstract

This was a prospective, multicenter, 24-week observational study of the effectiveness and safety of biphasic insulin aspart 30 (BIAsp 30; NovoMix® 30) in type 1 and type 2 diabetes patients under normal clinical practice conditions in Macedonia. Results presented are for 2196 patients from 30 diabetes centers (41.2% male; mean age 59.6±11.1 y; type 2 diabetes 95.7%; diabetes’ duration 9.0±6.7 y; BMI 28.0±4.5 kg/m2) inadequately controlled on prior treatment (46.7% with OAD; 48.7% with insulin). Most patients (89.3%) were initiated with and completed the study (86.7%) on twice-daily BIAsp 30. Baseline and 24-wk total daily insulin doses (U/day) were 39.8±13.8 and 45.8±14.0, respectively. At 24 weeks, mean HbA1c and 8-point PG profile were significantly improved vs. baseline. The proportion of patients achieving target HbA1c <7% increased from baseline (3.9% vs. 31.8% at wk 24). Mean weight was not significantly increased from 76.4±12.8 kg at baseline to 76.7±12.5 kg at wk 24. No episodes of major hypoglycemia were reported, and no other safety issues were raised during the study treatment. This study provides supportive evidence on the role of BIAsp 30 in the treatment of diabetes mellitus in routine clinical practice. Further dose optimization is necessary to increase the number of patients achieving target HbA1c.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Ivica Smokovski
Date Deposited: 28 Dec 2015 13:03
Last Modified: 28 Dec 2015 13:03
URI: http://eprints.ugd.edu.mk/id/eprint/14628

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