Reduction of absolute risk for coronary artery disease in type 2 diabetes patients as assessed by UKPDS model 6 months after initiation of insulin treatment

Smokovski, Ivica and Georgiev, Antonio and Pavlovka, Kristina and Georgieva, Daniela (2009) Reduction of absolute risk for coronary artery disease in type 2 diabetes patients as assessed by UKPDS model 6 months after initiation of insulin treatment. Medicus, 12 (2). pp. 22-26. ISSN 1409-6366

[img]
Preview
Text
Medikus 2a.pdf

Download (916Kb) | Preview

Abstract

Objective: To assess a difference in 10-year absolute risk of coronary artey disease (CAD) in type 2 diabetes mellitus (DM) patients without CVD and microalbuminuria not using statin treatment by the system for risk assessment UKPDS prior to and 6 months after initiation of insulin treatment, and to identify the number of patients requiring statin treatment after 6 months of insulin treatment. Material and methods: Observational, cross-sectional study of 516 patients with DM type 2 without CVD and microalbuminuria not using statin treatment prior to and 6 months after initiation of insulin treatment. Results: Mean 10-year absolute risk of CAD assessed by UKPDS model after insulin treatment was significantly reduced compared to the risk before insulin treatment (15.6 ± 10.1 vs 20.3 ± 12.3%, p<0.001). Increased risk (>15%) and total cholesterol ≥5 mmol/l was identified in consideable number of patients (n=187; 36.2%) after 6 months of insulin treatment. Conclusion: Use of UKPDS model in the cohort of type 2 DM patients without CVD and microalbuminuria not using statin treatment, identified reduction of mean 10-year absolute risk of CAD after 6 months of insulin treatment and confirmed the need of CVD primary prevention with statin treatment in 187 patients (36.2%) of the studied cohort.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Ivica Smokovski
Date Deposited: 28 Dec 2015 11:17
Last Modified: 28 Dec 2015 11:18
URI: http://eprints.ugd.edu.mk/id/eprint/14619

Actions (login required)

View Item View Item