Estimation of number of diabetic patients requiring primary prevention for coronary heart disease

Smokovski, Ivica and Pavlovska, Krisitina and Davceva, Jelka (2010) Estimation of number of diabetic patients requiring primary prevention for coronary heart disease. Physioacta, 4 (2). pp. 105-114. ISSN 1857-5587

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Abstract

Aim: Estimation of number of subjects with type 2 diabetes mellitus (DM) in Republic of Macedonia, who are not receiving, but are eligible for statin treatment as primary prevention of coronary heart disease (CHD), and assessment of financial implications for the additional use of statin treatment. Material and methods: Observational, cross-sectional study of 516 patients with DM type 2 without cardiovascular diseases and not receiving statin treatment. Subjects were identified by the risk for CHD estimated with models based on United Kingdom Prospective Diabetes Study (UKPDS) and Framingham study, and as recommended by Heart Protection Study (HPS) and Collaborative Atorvastatin Diabetes Study (CARDS). Results: UKPDS and Framingham models identified additional 15,895 and 19,550 subjects, respectively (0.77% and 0.95% of total population in Republic of Macedonia), if CHD risk higher than 15% and total cholesterol > 5 mmol/l. HPS and CARDS studies identified 41,650 and 42,160 subjects, respectively (2.03% and 2.05% of total population in Republic of Macedonia). Financial implications of additional use of statin treatment were in range of 0.66% to 1.76% of the total budget planned for drugs in Republic of Macedonia. Conclusion: Application of different methods identified considerable number of patients with DM type 2, who are not receiving, but are eligible for statin treatment; individual assessment of CHD risk is required to introduce statin treatment as primary prevention.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Ivica Smokovski
Date Deposited: 21 Dec 2015 09:05
Last Modified: 21 Dec 2015 09:05
URI: http://eprints.ugd.edu.mk/id/eprint/14607

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