Heroin dependents are insulin resistant

Janikevik Ivanovska, Danijela and Subeska Stratrova, Slavica and Pereska, Zanina and Mecevska Jovcevska, Jasmina (2011) Heroin dependents are insulin resistant. In: IFCC Worldlab Berlin 2011, 15-19 May 2011, Berlin, Germany.

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Background. Fasting insulin levels, HOMA-IR and HOMA-%B are precise methods for determining insulin resistance and can be used in assessing the insulin sensitivity in heroin dependents (HD). Heroin dependents are expected to be insulin resistant. To determine the heroin influence on insulin sensitivity in male heroin dependents compared to control healthy male (K). Materials. Fasting insulin levels (I), HOMA-IR, HOMA-%B, fasting glucose levels (gl) and C-peptide (C) were determined in both groups, group K with mean age (28.1±4.2 yr) and mean BMI (22.8±2.5 kg/m2), not different compared to group HD with mean age (27.9±5.4 yr) and BMI (22.3±3.1 kg/m2),which were HCV negative. Methods. I and C were determined with hemiluminiscentmethod on Immunology Analyzer Immulate2000, HOMA-IR was calculated [(FIxFgl)/22.5], as well as HOMA-%B [(20xFI)/(Fgl-3.5)]. Results. I values in HD group were 15.24±27.6 IU/L, significantly higher compared to K (4.58±3.23) (p<0.035). Glucose levels were not significantly different between HD (5.0±0.83 mmol/l) and K (4.93±0.45 mmol/l) (p>0.05). HOMA-IR in HD (2.52±3.29) and HOMA-%B (111.56±58.14) were significantly higher compared to the correspondent values in K (1.02±0.8) (p<0.016) and (68.83±46.57) (p<0.05). I values correlated highly significantly positively with HOMA-IR, HOMA-%B and C-peptide (p<0.0001) in HD. Conclusions. HD were characterized with significantly higher I, HOMA-IR, HOMA-%B values, which correlated highly significantly between themselves, confirming insulin resistance in HD.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Danijela Janikevik
Date Deposited: 14 Dec 2015 14:10
Last Modified: 21 Dec 2015 09:16
URI: http://eprints.ugd.edu.mk/id/eprint/14460

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