Voltammetric insights in the transfer of ionizable drugs across biomimetic membranes: recent achievements.

Gulaboski, Rubin and Borges, Fernanda and Pereira, Carlos M. and Cordeiro, M Natália D S and Garrido, Jorge and Silva, A. Fernando (2007) Voltammetric insights in the transfer of ionizable drugs across biomimetic membranes: recent achievements. Combinatorial chemistry & high throughput screening, 10 (7). pp. 514-26. ISSN 1386-2073

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Abstract

The latest results of voltammetric research on the ionic transfer process of ionisable drugs across bare and lipid-modified liquid-liquid interfaces are reviewed. In recent years, two voltammetric methods have been extensively applied to this purpose, i.e. the classical four electrode voltammetry at the interface between two immiscible electrolyte solutions, and the "three-phase electrode." Thus, a brief background of the methodologies and some successful examples of their application are highlighted in this work. Particular attention is given to the ionic transfer kinetics and to the electrochemical characterization of the drug-membrane interactions between the ionized drugs and lipid-modified interfaces. Future trends in this area are also mentioned in connection with high-throughput assessment of ADMET properties of drugs.

Item Type: Article
Uncontrolled Keywords: ionizable drugs, voltammetry, ion transfer, biomimetic membranes, lipophilicity, partition,
Subjects: Natural sciences > Chemical sciences
Divisions: Faculty of Agriculture
Depositing User: Rubin Gulaboski
Date Deposited: 31 Oct 2012 12:30
Last Modified: 05 Nov 2012 11:20
URI: http://eprints.ugd.edu.mk/id/eprint/137

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