Association of GPX1 polymorphism, GPX activity and prostate cancer risk

Erdem, Onur and Eken, Ayse and Akay, Cemal and Arsova-Sarafinovska, Zorica and Matevska, Nadica and Suturkova, Ljubica and Erten, Koray and Ozgok, Yasar and Dimovski, Aleksandar and Sayal, Ahmet and Aydin, Ahmet (2012) Association of GPX1 polymorphism, GPX activity and prostate cancer risk. Human and Experimental Toxicology, 31 (1). pp. 24-31. ISSN 0960-3271

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Prostate cancer is the second most common cancer in men worldwide. Although the etiology of this disease remains largely unclear, several lines of evidence suggest that oxidative stress plays a role in prostate carcinogenesis. The antioxidant enzyme glutathione peroxidase 1 (GPX1) is part of the enzymatic antioxidant defense, preventing oxidative damage to DNA, proteins and lipids by detoxifying hydrogen and lipid peroxides that may contribute to prostate cancer development. Some studies indicate an association between GPX1 Pro198Leu polymorphism and an increased risk of cancer. The purpose of the present study was to determine the possible association of GPX1 Pro198Leu polymorphism and erythrocyte GPX activity with the risk of developing prostate cancer and to clarify whether erythrocyte GPX activity levels were correlated with the GPX1 Pro198Leu genotype in the Turkish population. The GPX1 Pro198Leu genotype was determined in 33 prostate cancer patients and 91 control individuals. As evident from our results, there was no difference between genotype and/or allele frequencies in prostate cancer patients and controls. No significant difference was found in GPX1 genotype or allele frequency between aggressive and non-aggressive prostate cancer patients. It can be suggested with these findings that individual susceptibility of prostate cancer may be modulated by GPX1 polymorphism, but it needs further studies.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Zorica Arsova Sarafinovska
Date Deposited: 02 Jun 2015 09:33
Last Modified: 02 Jun 2015 09:33

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