Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer

Arsova-Sarafinovska, Zorica and Eken, Ayse and Matevska, Nadica and Erdem, Onur and Sayal, Ahmet and Savaser, Ayhan and Banev, Saso and Petrovski, Daniel and Dzikova, Sonja and Georgiev, Vladimir and Sikole, Aleksandar and Ozgok, Yasar and Suturkova, Ljubica and Dimovski, Aleksandar and Aydin, Ahmet (2009) Increased oxidative/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer. Clinical Biochemistry, 42 (12). pp. 1228-1235. ISSN 0009-9120

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Objectives The study was aimed to evaluate the oxidative/nitrosative stress status in prostate cancer (CaP) and benign prostatic hyperplasia (BPH). Design and methods 312 men from two different populations were included: 163 men from Macedonia (73 CaP patients, 67 BPH patients and 23 control subjects) and 149 men from Turkey (34 prostate cancer patients, 100 BPH patients and 15 control subjects). We measured erythrocyte malondialdehyde (MDA) levels, erythrocyte activities of superoxide dismutase (CuZn-SOD), glutathione peroxidase (GPX) and catalase (CAT); plasma nitrite/nitrate (NO2−/NO3−), cGMP and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels. Results A similar pattern of alteration in the oxidative/nitrosative stress-related parameters was found in both, Macedonian and Turkish studied samples: higher MDA concentrations with lower GPX and CuZn-SOD activities in CaP patients versus controls and BPH groups. The CAT activity was decreased in the CaP patients versus controls in the Turkish studied sample. Furthermore, CaP patients had increased plasma NO2−/NO3− and cGMP levels versus controls and BPH groups in both studied samples. Conclusions This study has confirmed an imbalance in the oxidative stress/antioxidant status and revealed an altered nitrosative status in prostate cancer patients.

Item Type: Article
Subjects: Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Zorica Arsova Sarafinovska
Date Deposited: 02 Jun 2015 09:30
Last Modified: 02 Jun 2015 09:30

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