Chapter 8. Labelling of biotin with 188Re

Pasquali, Micol and Janevik-Ivanovska, Emilija and Uccelli, Licia and Boschi, Alessandra and Duatti, Adriano (2015) Chapter 8. Labelling of biotin with 188Re. In: Yttrium-90 and Rhenium-188 Radiopharmaceuticals for Radionuclide Therapy. IAEA Radioisotopes and Radiopharmaceuticals (5). International Atomic Energy Agency, Publishing Section, Vienna, pp. 120-133. ISBN ISSN 2077–6462

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Abstract

Different chemical strategies have been employed for labelling biotin using 188Re with the aim to develop a sterile and pyrogen free kit formulation that is suitable for clinical use. A number of biotin conjugated 188Re complexes were prepared and evaluated to determine their affinity for avidin. The most difficult challenge was to devise an efficient reaction pathway that was able to obtain the final radiocompounds in a high radiochemical yield. This work describes the molecular design and the chemical strategy that were followed to obtain reliable preparation of the new radiopharmaceuticals starting from generator produced [188ReO4]–.

Item Type: Book Section
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health biotechnology
Divisions: Faculty of Medical Science
Depositing User: Emilija Janevik
Date Deposited: 18 May 2015 08:59
Last Modified: 18 May 2015 08:59
URI: http://eprints.ugd.edu.mk/id/eprint/13173

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