The activities of the aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase enzymes in the blood serum of rats in conditions of chronic lead poisoning

Stavreva Veselinovska, Snezana (2016) The activities of the aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase enzymes in the blood serum of rats in conditions of chronic lead poisoning. In: Seminar of Ecology with International Participation– 2015, Section “Biology”.

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Abstract

Aim: The aim of this study was to analyze the activities of the AST (Aspartate Aminotransferase (AST), ALT (alanine aminotransferase) and ALP (alkaline phosphatase) enzymes in the blood serum of rats in conditions of chronic lead poisoning. Material and methods: Research included: 40 female rats of the strain, weighing about 150-200 gr, and 4-5 months of age and 10 young offspring of the above females, 1.5 months old and about 80-100 gr of weight. Lead in the form of lead – acetate Pb (CH3COO)2 was given to female rats orally, by means of water. Results: In conditions of chronic lead poisoning of female rats and their offspring a significant increase in the activities of AST, ALT and ALP enzymes in the blood sera of experimental groups in relation to the control ones was determined. A higher dose of lead resulted in a more significant increase of ALP activity in the blood sera of female rats. Conclusion: The activities of AST, ALT and ALP enzymes in the blood serum of young rats were significantly increased in conditions of chronic lead poisoning of their mothers during periods of pregnancy and lactation, but dependence on the dose of lead being received by their mothers was not established. Key words: Lead, AST (Aspartate Aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), chronic lead poisoning.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Lead, AST (Aspartate Aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), chronic lead poisoning.
Subjects: Natural sciences > Biological sciences
Divisions: Faculty of Natural and Technical Sciences
Depositing User: Snezana Stavrova Veselinova
Date Deposited: 07 Jul 2016 10:21
Last Modified: 07 Jul 2016 10:21
URI: http://eprints.ugd.edu.mk/id/eprint/13104

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