Genotoxicological effects of heavy metals on humans cells

Velickova, Nevenka and Kamcev, Nikola (2014) Genotoxicological effects of heavy metals on humans cells. American Journal of Environmental Protection, 2 (4). pp. 71-73. ISSN 2328-7233

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Abstract

Aims of this study was to detect cytogenetic damage in mine workers working in a lead–zinc mine, which could be associated with a combined exposure to lead, zinc and cadmium. Methods: This study involved 120 mine workers from the lead–zinc mine in Macedonia, and control group (30) local people who had never worked in the mine. The authors used peripheral blood lymphocytes as the target material. The total share of structural chromosome aberration (SCA) are search out over the 3 years of monitoring. Also they measured the blood level of lead, zinc and cadmium with ISP-AES. Results: The authors concluded increased blood lead level in exposed group (Mean= O,089mg/l) and in 20% in control group (Mean=0,066mg/l); increased zinc blood level in exposed (Mean=1,391mg/l) and in control group (Mean=1,074mg/l); increased cadmium blood level in 62% of exposed (Mean=0,007mg/l) and in 50% of control group (Mean=0,006mg/l); Chromosomal aberrations (like dicentric and acentric chromosome) were found to be elevated in 7% of exposed individuals (mine workers) non in the control group. Both chromosome type aberrations in the exposed group were accompanied with anemia, leucocitosis and anisocitosis. Conclusion: Group of exposed persons showing increased levels of chromosome abnormalities has a higher risk of developing cancer and other deseasses. Key words: genotoxic agents, heavy metals, professionally exposed

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Nevenka Velickova
Date Deposited: 10 Dec 2014 09:02
Last Modified: 10 Dec 2014 09:02
URI: http://eprints.ugd.edu.mk/id/eprint/11638

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