Мозочен натриуретичен пептид кај пациенти со срцева слабост во корелација со традиционалните биомаркери на бубрежната функција

Naumovska, Marija (2014) Мозочен натриуретичен пептид кај пациенти со срцева слабост во корелација со традиционалните биомаркери на бубрежната функција. Other thesis, Универзитет „Гоце Делчев“ - Штип.

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Мозочен натриуретичен пептид кај пациенти со срцева слабост, во корелација со традиционалните био.pdf

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Abstract

During the treatment of heart failure worsening of renal function often occurs and results in a complex clinical course. Furthermore, renal dysfunction is a strong independent predictor of longterm adverse outcomes in patients with hart failure. Heart failure is a major source of hospitalization and mortality. Patients with heart failure usually present with severe dyspnea due to pulmonary congestion which is the hallmark of heart failure. Therefore, elimination of excess fluid should be the primary target of treatment. Also, there is substantial evidence that fluid accumulation is associated with morbidity, mortality, and readmission with heart failure. Kidney is the main release of congestion, but many of heart failure patients have accompanying renal dysfunction or experience worsening of renal function during hospitalization. The heart and kidney are very closely related. Thus, impairment of cardiac function can make renal dysfunction, recently referred to as “cardiorenal syndrome” or inversely as “renocardiac syndrome”. The venrticles of heart secrete brain natriuretic peptide (BNP). Circulating BNP level increases proportionally in relation to the severity of heart failure. Thus, with minimal symptoms of heart failure BNP is detected in the circulation. As biomarkers of renal function were examined urea and creatinine. Urea (BUN) is produced as a metabolic product of protein. 90 % of urea is excreted through the kidneys. Creatinine (CREA) is a product of muscle metabolism, produced as a result of degradation of creatine and phosphocreatine. This study included fifty patients with heart failure. Concentrations of BNP, urea and creatinine were measured before surgery and postoperatively. The statistical processing was performed on correlation between each of theem.

Item Type: Thesis (Other)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Katerina Hadzi-Vasileva
Date Deposited: 14 Aug 2014 13:25
Last Modified: 13 Mar 2015 10:23
URI: http://eprints.ugd.edu.mk/id/eprint/10602

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