Determination of Ketoconazole in Pharmaceutical Formulations

Gjorgjeska, Biljana (2014) Determination of Ketoconazole in Pharmaceutical Formulations. Journal of Pharmacy and Pharmacology, 2 (3). pp. 226-229. ISSN 2328-2150

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Official URL: http://www.davidpublishing.org/show.html?16363

Abstract

Ketoconazole has been widely used as an antifungal drug that is formulated as tablets, cream and over-the-counter ketoconazole shampoo. The aim of this research was to study and to standardize an UV (ultraviolet spectrophotometric) method, potentiometry and a HPLC (high performance liquid chromatographic) method for the determination of ketoconazole in commercially available tablets. These three methods were compared and discussed with respect to their sensitivity, selectivity and ready-applicability in routine analytical work. Absorption spectra and spectrophotometric determinations were carried out on the UV spectrophotometer. Investigated concentrations that ranged from 0.003 mg•dm-3 to 0.02 mg•dm-3.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health biotechnology
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 27 Jun 2014 10:03
Last Modified: 27 Jun 2014 10:03
URI: http://eprints.ugd.edu.mk/id/eprint/10234

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